btt Medical Institute provides physician-guided care for patients with complex neurological conditions and oncology-related needs through brain-guided thermodynamics.
Brain First
Most treatments focus on the disease.
We start where regulation begins.
The brain helps coordinate inflammation, recovery, immune response, movement, sleep, metabolism — and shapes how the body adapts under stress.
At btt Medical Institute, physicians use brain-guided thermodynamics to better understand and support those regulatory systems through personalized thermal therapies.
Our goal is not simply to manage symptoms. It is to support the biological conditions that favor function, adaptation and quality of life.
How Brain-Guided
Thermodynamics Works
One of the body's natural responses to elevated temperature is the production of Heat Shock Proteins (HSPs)—specialized proteins that help protect cells during periods of physiological stress. Often described as the body's molecular repair system, HSPs assist in refolding damaged proteins, removing toxic protein aggregates, supporting cellular repair, and maintaining healthy protein balance throughout the body.
Many neurodegenerative diseases—including Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease, and Alzheimer's disease—as well as several forms of cancer have been associated with abnormal protein folding and the accumulation of dysfunctional proteins. By precisely guiding controlled temperature through the brain's own thermoregulatory pathways, Computerized Brain-Guided Thermal Therapy (CBIT), an investigational therapy, is designed to activate the body's natural heat shock response, supporting these protective cellular mechanisms in a controlled and personalized way.
- Comprehensive medical evaluation
- Physician supervision
- Continuous monitoring
- Personalized protocols
- Ongoing follow-up
The science behind every protocol.
Behind every protocol are more than two decades of scientific research.
btt Medical Institute is built on Dr. Marc Abreu's Brain-Eyelid Thermal Regulatory Tunnel discovery and a growing body of research exploring the relationship between brain temperature, cellular repair, inflammation and human physiology.
Our clinical work continues to evolve through scientific publications, documented patient outcomes and ongoing research.
Explore Our ResearchWhat makes btt Medical Institute different?
Physician-guided
care
Every patient is evaluated and supervised by our medical team.
Personalized treatments
Protocols are adapted to each patient's diagnosis, physiology and response.
Brain-guided thermodynamics
Thermal therapies are guided using proprietary technology that continuously monitors brain-connected thermal signals.
Noninvasive approach
No surgery.
No direct access to the brain.
Conditions we
currently evaluate
btt Medical Institute works with patients facing complex medical challenges who are seeking to understand whether brain-guided thermodynamics may be appropriate for their care. Areas commonly reviewed include:
Contact Us- spinocerebellar ataxias
- multiple system atrophy
- spinal muscular atrophy
- dementia
- Alzheimer's disease
- Huntington's disease
- Parkinson's disease
- amyotrophic lateral sclerosis
- breast cancer
- prostate cancer
- lung and bronchial cancer
- colorectal cancer
- melanoma
- bladder cancer
- kidney cancer
- non-Hodgkin lymphoma
- multiple sclerosis
- epilepsy
- transverse myelitis
- Lyme disease
- herpes
- lupus
Every patient is evaluated individually. Eligibility is determined through a clinical review process and physician assessment.
What our patients say
Hear directly from patients about their experiences with btt.
What Changed After 10 Years Living With Parkinson's?
Patient story
An ALS Diagnosis Broke Us... Until We Found This
Patient story
Individual experiences vary. Patient stories are not evidence that any therapy is safe or effective.
The btt Experience
Every patient begins with a clinical review process designed to determine whether btt's approach may be appropriate for their condition and goals.
- Step 1
btt Assessment
Complete the form on our website and schedule a complimentary consultation with our Patient Care Team.
- Step 2
Clinical Evaluation
Following the online assessment, our clinical team will review your medical records and determine whether you are eligible for treatment.
- Step 3
Treatment Care at Our Institute
Eligible patients travel to our institute in Aventura, Florida, for 5 consecutive days of physician-guided treatment care.
- Step 4
Long-Term Follow-Up
After treatment care, our team provides remote follow-up and ongoing support for up to five years.
Common questions
about btt Medical Institute
Quick answers about treatment, eligibility, and what to expect.
Is btt Medical Institute's treatment only available in Florida, USA?+
Yes. At present, treatment is provided only at our institute in Aventura, Florida, just north of Miami.
Where is btt Medical Institute located?+
We are located in Aventura, Florida, USA — just 30 minutes south of Fort Lauderdale-Hollywood International Airport or 40 minutes north of Miami International Airport. Our addresses are: South Unit: 17501 Biscayne Boulevard, Suite 470, Aventura, FL 33160 North Unit: 20295 NE 29th Place, Suite 300, Aventura, FL 33180
How many sessions are required for treatment at btt Medical Institute?+
There is no fixed number of sessions per condition. Your treatment plan will be personalized and adjusted according to your brain's specific response throughout your care journey. Since the treatment care is guided by each patient's brain thermodynamics — which are as unique as fingerprints — the response is entirely individual.
Is the heat generated during the treatment similar to a sauna?+
No. The heat produced during treatment at btt Medical Institute is entirely different from sauna heat. While a sauna heats the body in a superficial and generalized way, our investigational brain-guided thermal therapy uses advanced technology to precisely and safely modulate temperature under continuous physician supervision — guided by the brain's own thermal signals — aligned with the body's natural thermoregulation mechanisms. Based on personalized frequencies and thermodynamic patterns, the treatment is designed to activate deep biological processes, such as the induction of heat shock proteins (HSPs) and anti-inflammatory molecules — effects that cannot be achieved through sauna heat. In short: although both involve heat, their application and purpose are completely distinct.
How many days will I need to stay in Aventura for treatment with Dr. Marc Abreu?+
The protocol typically requires a stay of 5 consecutive days in Aventura, Florida.
Can I bring a companion?+
Yes, having a companion is mandatory during the treatment session days at btt Medical Institute. Your companion plays an essential role in your treatment care journey.
Which conditions can be treated at btt Medical Institute?+
Some of the conditions treated include Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, ataxia, certain types of metastatic cancers (e.g., pancreatic, prostate, testicular, ovarian), multiple sclerosis, and Lyme disease. Other applicable conditions include Lupus, Machado-Joseph disease, Spinal Muscular Atrophy, Spinocerebellar Ataxia, Multiple System Atrophy, Cognitive Decline, Progressive Supranuclear Palsy, Spastic Paralysis, Encephalopathy, Vulpian-Bernhardt Syndrome, and more.
How can I begin treatment at btt Medical Institute?+
Fill out the application form available on our website. Our Patient Care Team will contact you to coordinate the next steps.
Take The Next Step
The first step is a clinical evaluation. Our team will review your history, discuss your goals and help determine whether brain-guided thermodynamics may be appropriate for your care journey.
Contact btt